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SIRT1 activation synergizes with FXR agonism in hepatoprotection via governing nucleocytoplasmic shuttling and degradation of FXR

Farnesoid X receptor (FXR) is widely accepted as a promising target for various liver diseases; however, panels of ligands in drug development show limited clinical benefits, without a clear mechanism. Here, we reveal that acetylation initiates and orchestrates FXR nucleocytoplasmic shuttling and th...

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Main Authors: Shuang Cui, Huijian Hu, An Chen, Ming Cui, Xiaojie Pan, Pengfei Zhang, Guangji Wang, Hong Wang, Haiping Hao
Format: Artigo
Language:Inglês
Published: Elsevier 2023-02-01
Series:Acta Pharmaceutica Sinica B
Subjects:
FXR
Nuclear receptor
Acetylation
Phosphorylation
Nucleocytoplasmic shuttling
Degradation
Online Access:http://www.sciencedirect.com/science/article/pii/S2211383522003707
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