Antibody Afucosylation Augments CD16-Mediated Serial Killing and IFNγ Secretion by Human Natural Killer Cells

One mechanism by which monoclonal antibodies (mAb) help treat cancer or autoimmune disease is through triggering antibody-dependent cellular cytotoxicity (ADCC) via CD16 on Natural Killer (NK) cells. Afucosylation is known to increase the affinity of mAbs for CD16 on NK cells and here, we set out to...

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Hlavní autoři:	Alexandros Karampatzakis, Petr Brož, Camille Rey, Björn Önfelt, Gabriela Dos Santos Cruz De Matos, Daniel Rycroft, Ashley Ambrose, Daniel M. Davis
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Frontiers Media S.A. 2021-03-01
Edice:	Frontiers in Immunology
Témata:	Natural Killer cells antibody dependent cellular cytotoxicity Fc receptors afucosylation cellular activation immune synapse
On-line přístup:	https://www.frontiersin.org/articles/10.3389/fimmu.2021.641521/full
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