Oxymatrine, a novel TLR2 agonist, promotes megakaryopoiesis and thrombopoiesis through the STING/NF-κB pathway

Radiation-induced thrombocytopenia (RIT) faces a perplexing challenge in the clinical treatment of cancer patients, and current therapeutic approaches are inadequate in the clinical settings. In this research, oxymatrine, a new molecule capable of healing RIT was screened out, and the underlying reg...

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Principais autores:	Chengyang Ni, Ling Zhou, Shuo Yang, Mei Ran, Jiesi Luo, Kui Cheng, Feihong Huang, Xiaoqin Tang, Xiang Xie, Dalian Qin, Qibing Mei, Long Wang, Juan Xiao, Jianming Wu
Formato:	Artigo
Idioma:	Inglês
Publicado:	Elsevier 2025-01-01
Series:	Journal of Pharmaceutical Analysis
Assuntos:	Oxymatrine Megakaryocyte differentiation Thrombopoiesis Platelets Toll-like receptor 2
Acceso en liña:	http://www.sciencedirect.com/science/article/pii/S2095177924001515
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