Inhibition of IκB kinase reduces the multiple organ dysfunction caused by sepsis in the mouse
SUMMARY Nuclear factor κB (NF-κB) plays a pivotal role in sepsis. Activation of NF-κB is initiated by the signal-induced ubiquitylation and subsequent degradation of inhibitors of kappa B (IκBs) primarily via activation of the IκB kinase (IKK). This study was designed to investigate the effects of I...
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| Hauptverfasser: | , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
The Company of Biologists
2013-07-01
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| Schriftenreihe: | Disease Models & Mechanisms |
| Online-Zugang: | http://dmm.biologists.org/content/6/4/1031 |
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