IGF2BP3-dependent glutamine/BCAA metabolic rewiring rejuvenates aged human adipose-derived stem cells for enhanced tissue regeneration

Abstract Aging impairs the regenerative capacity and differentiation potential of human adipose-derived stem cells (hASCs), but the mechanisms underlying their functional decline remain unclear. Through systematic functional assays and in vivo experiments, we first confirmed age-associated reduction...

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Autors principals:	Zichao Li, Lin Feng, Xinxin Wei, Huichen Li, Yifu Zhu, Hongtao Wang, Jiaqi Liu, Liang Luo, Zhao Zheng, Baoqiang Song, Liangliang Shen, Dahai Hu
Format:	Artigo
Idioma:	Inglês
Publicat:	Nature Publishing Group 2026-01-01
Col·lecció:	Cell Discovery
Accés en línia:	https://doi.org/10.1038/s41421-025-00860-7
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