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FGFR signaling establishes spatial gradients of secretory cell identities along the airway proximal-distal axis

Abstract Secretory cells are major structural and functional constituents of the lung airways. Their heterogeneity, spatial organization and specification mechanisms are partially understood. Here, we analyze secretory lung cell-types at single-cell resolution. In the airway epithelium, we find oppo...

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Bibliographic Details
Main Authors: Alexandros Sountoulidis, Jonas Theelke, Andreas Liontos, Alexandra B. Firsova, Orane Eliot, Janine Koepke, Pamela Millar-Büchner, Louise Mannerås-Holm, Åsa Björklund, Athanasios Fysikopoulos, Antonia Kelm, Eleni Bouloukou, Konstantin Gaengel, Fredrik Bäckhed, Christer Betsholtz, Werner Seeger, Saverio Bellusci, Christos Samakovlis
Format: Artigo
Language:Inglês
Published: Nature Portfolio 2026-03-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-026-70842-0
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