Assessing the Functional Relevance of Variants in the IKAROS Family Zinc Finger Protein 1 (IKZF1) in a Cohort of Patients With Primary Immunodeficiency

Common variable immunodeficiency (CVID) is the most frequent symptomatic primary immunodeficiency. Patients with CVID are prone to recurrent bacterial infection due to the failure of adequate immunoglobulin production. Monogenetic defects have been identified in ~25% of CVID patients. Recently, muta...

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Principais autores:	Zoya Eskandarian, Manfred Fliegauf, Alla Bulashevska, Michele Proietti, Rosie Hague, Cristian Roberto Smulski, Desirée Schubert, Klaus Warnatz, Bodo Grimbacher
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Frontiers Media S.A. 2019-04-01
coleção:	Frontiers in Immunology
Assuntos:	CVID monogenic defects IKAROS TRAIL DNA binding nuclear localization
Acesso em linha:	https://www.frontiersin.org/article/10.3389/fimmu.2019.00568/full
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