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The impact of adverse childhood experiences on DNA methylation age: a systematic review and meta-analysis

Abstract Adverse childhood experiences (ACEs), such as abuse and neglect, are associated with poor health in adulthood. One proposed biological mechanism linking early adversity to health outcomes is epigenetic age acceleration (EAA), a measure of biological aging derived from DNA methylation. Under...

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Bibliographic Details
Main Authors: Hannah Russell, Gregor Angus, Sam Singleton, Christopher G. Bell, Tim G. Hales
Format: Artigo
Language:Inglês
Published: BMC 2026-01-01
Series:Clinical Epigenetics
Subjects:
Online Access:https://doi.org/10.1186/s13148-025-02047-z
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