1,25(OH)2D3 and dexamethasone additively suppress synovial fibroblast activation by CCR6+ T helper memory cells and enhance the effect of tumor necrosis factor alpha blockade

Abstract Background Despite recent improvements in the treatment of rheumatoid arthritis (RA), an insufficient treatment response and the development of treatment resistance in many patients illustrates the need for new therapeutic strategies. Chronic synovial inflammation could be suppressed by tar...

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Principais autores:	Wendy Dankers, Claudia González-Leal, Nadine Davelaar, Patrick S. Asmawidjaja, Adriana M. C. Mus, Johanna M. W. Hazes, Edgar M. Colin, Erik Lubberts
Formato:	Artigo
Idioma:	Inglês
Publicado em:	BMC 2018-09-01
coleção:	Arthritis Research & Therapy
Assuntos:	Rheumatoid arthritis Th17 Vitamin D Dexamethasone CCR6
Acesso em linha:	http://link.springer.com/article/10.1186/s13075-018-1706-9
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