BRAF(V600E) mutation together with loss of Trp53 or pTEN drives the origination of hairy cell leukemia from B-lymphocytes

Abstract Hairy cell leukemia (HCL) is a B-lymphoma induced by BRAF(V600E) mutation. However, introducing BRAF(V600E) in B-lymphocytes fails to induce hematological malignancy, suggesting that BRAF(V600E) needs concurrent mutations to drive HCL ontogeny. To resolve this issue, here we surveyed human...

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Auteurs principaux:	Jiajun Yap, Jimin Yuan, Wan Hwa Ng, Gao Bin Chen, Yuen Rong M. Sim, Kah Chun Goh, Joey Teo, Trixie Y. H. Lim, Shee Min Goay, Jia Hao Jackie Teo, Zhentang Lao, Paula Lam, Kanaga Sabapathy, Jiancheng Hu
Format:	Artigo
Langue:	Inglês
Publié:	BMC 2023-08-01
Collection:	Molecular Cancer
Sujets:	Hairy cell leukemia BRAF(V600E) Tumor suppressor RAS/RAF/MEK/ERK signaling B cell biology B cell lymphoma
Accès en ligne:	https://doi.org/10.1186/s12943-023-01817-8
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