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The impact of selective HDAC inhibitors on the transcriptome of early mouse embryos

Abstract Background Histone acetylation, which is regulated by histone acetyltransferases (HATs) and histone deacetylases (HDACs), plays a crucial role in the control of gene expression. HDAC inhibitors (HDACi) have shown potential in cancer therapy; however, the specific roles of HDACs in early emb...

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Principais autores: Ruiqi Shao, Takayoshi Suzuki, Mikita Suyama, Yuichi Tsukada
Formato: Artigo
Idioma:Inglês
Publicado: BMC 2024-02-01
Series:BMC Genomics
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Acceso en liña:https://doi.org/10.1186/s12864-024-10029-3
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