Distinct mechanisms regulate Lck spatial organization in activated T cells

Phosphorylation of the T cell receptor (TCR) by the kinase Lck is the first detectable signaling event upon antigen engagement. The distribution of Lck within the plasma membrane, its conformational state, kinase activity and protein interactions all contribute to determine how efficiently Lck phosp...

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Autors principals:	Natasha eKapoor-Kaushik, Elizabeth eHinde, Ewoud Bernardus Compeer, Yui eYamamoto, Felix eKraus, Zhengmin eYang, Jieqiong eLou, Thibault eTabarin, Sophie Victoria Pageon, Katharina eGaus, Jeremie eRossy
Format:	Artigo
Idioma:	Inglês
Publicat:	Frontiers Media S.A. 2016-03-01
Col·lecció:	Frontiers in Immunology
Matèries:	Lck T cell signaling Membrane organization image correlation spectroscopy Super-resolution fluorescence microscopy assembly of signaling complexes
Accés en línia:	http://journal.frontiersin.org/Journal/10.3389/fimmu.2016.00083/full
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