Design, synthesis and biological evaluation of 2-((4-sulfamoylphenyl)amino)-pyrrolo[2,3-d]pyrimidine derivatives as CDK inhibitors

To explore the potential use of CDK inhibitors in pancreatic ductal adenocarcinoma (PDAC) therapy, a series of novel 2-((4-sulfamoylphenyl)amino)-pyrrolo[2,3-d]pyrimidine derivatives was designed, synthesised, and investigated for inhibition on both CDK kinase activity and cellular proliferation of...

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Autori principali:	Bo Yang, Yanni Quan, Wuli Zhao, Yingjie Ji, Xiaotang Yang, Jianrui Li, Yi Li, Xiujun Liu, Ying Wang, Yanping Li
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Taylor & Francis Group 2023-12-01
Serie:	Journal of Enzyme Inhibition and Medicinal Chemistry
Soggetti:	Cell cycle-dependent kinase inhibitor 2-((4-sulfamoylphenyl)amino)-pyrrolo[23-d]pyrimidine derivatives pancreatic ductal adenocarcinoma anti-proliferative activity oral pharmacokinetics
Accesso online:	https://www.tandfonline.com/doi/10.1080/14756366.2023.2169282
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