Mitochondria-targeted magnolol inhibits OXPHOS, proliferation, and tumor growth via modulation of energetics and autophagy in melanoma cells

Introduction: Melanoma is an aggressive form of skin cancer for which there are no effective drugs for prolonged treatment. The existing kinase inhibitor antiglycolytic drugs (B-Raf serine/threonine kinase or BRAF inhibitors) are effective for a short time followed by a rapid onset of drug resistanc...

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Ngā kaituhi matua:	Gang Cheng, Micael Hardy, Jacek Zielonka, Katherine Weh, Monika Zielonka, Kathleen A. Boyle, Mahmoud Abu Eid, Donna McAllister, Brian Bennett, Laura A. Kresty, Michael B. Dwinell, Balaraman Kalyanaraman
Hōputu:	Artigo
Reo:	Inglês
I whakaputaina:	Elsevier 2020-01-01
Rangatū:	Cancer Treatment and Research Communications
Ngā marau:	Bioenergetic metabolism Mitophagy Melanoma Mitochondria-targeted agents Oxidative phosphorylation
Urunga tuihono:	http://www.sciencedirect.com/science/article/pii/S2468294220300460
Ngā Tūtohu:	Tāpirihia he Tūtohu Kāore He Tūtohu, Me noho koe te mea tuatahi ki te tūtohu i tēnei pūkete!