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Plasticity-induced actin polymerization in the dendritic shaft regulates intracellular AMPA receptor trafficking

AMPA-type receptors (AMPARs) are rapidly inserted into synapses undergoing plasticity to increase synaptic transmission, but it is not fully understood if and how AMPAR-containing vesicles are selectively trafficked to these synapses. Here, we developed a strategy to label AMPAR GluA1 subunits expre...

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Principais autores: Victor C Wong, Patrick R Houlihan, Hui Liu, Deepika Walpita, Michael C DeSantis, Zhe Liu, Erin K O'Shea
Format: Artigo
Sprog:Inglês
Udgivet: eLife Sciences Publications Ltd 2024-08-01
Serier:eLife
Fag:
AMPA receptor
vesicle trafficking
synaptic plasticity
actin
CRISPR/Cas9
single-particle tracking
Online adgang:https://elifesciences.org/articles/80622
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