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SIRT1-dependent modulation of methylation and acetylation of histone H3 on lysine 9 (H3K9) in the zygotic pronuclei improves porcine embryo development

Abstract Background The histone code is an established epigenetic regulator of early embryonic development in mammals. The lysine residue K9 of histone H3 (H3K9) is a prime target of SIRT1, a member of NAD+-dependent histone deacetylase family of enzymes targeting both histone and non-histone substr...

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Principais autores: Katerina Adamkova, Young-Joo Yi, Jaroslav Petr, Tereza Zalmanova, Kristyna Hoskova, Pavla Jelinkova, Jiri Moravec, Milena Kralickova, Miriam Sutovsky, Peter Sutovsky, Jan Nevoral
Formato: Artigo
Idioma:Inglês
Publicado em: BMC 2017-11-01
coleção:Journal of Animal Science and Biotechnology
Assuntos:
Embryonic development
Epigenetics
H3K9 methylation
SIRT1
Sirtuin
Acesso em linha:http://link.springer.com/article/10.1186/s40104-017-0214-0
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