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The potential for transition metal-mediated neurodegeneration in amyotrophic lateral sclerosis

Modulations of the potentially toxic transition metals iron (Fe) and copper (Cu) are implicated in the neurodegenerative process in a variety of human disease states including amyotrophic lateral sclerosis (ALS). However, the precise role played by these metals is still very much unclear, despite co...

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Principais autores: David Benn Lovejoy, Gilles Jean-Luc Guillemin
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2014-07-01
Serier:Frontiers in Aging Neuroscience
Fag:
Amyotrophic Lateral Sclerosis
Copper
Iron
neurodegeneration
er stress
Transition metals
Online adgang:http://journal.frontiersin.org/Journal/10.3389/fnagi.2014.00173/full
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