Altered IHH signaling contributes to reduced chondrocyte proliferation in the growth plate of MPS VII mice

Bone elongation is driven by chondrocyte proliferation and hypertrophy in the growth plate. Both processes are modulated by multiple signaling pathways including the Indian Hedgehog (IHH) signaling pathway. Mucopolysaccharidoses (MPS) are a group of lysosomal storage disorders characterized by accum...

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Hlavní autoři:	Zhirui Jiang, Ainslie L.K. Derrick-Roberts, Sharon Byers
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Elsevier 2020-12-01
Edice:	Molecular Genetics and Metabolism Reports
Témata:	Mucopolysaccharidosis (MPS) Growth plate Chondrocyte proliferation Indian hedgehog (IHH) Bone shortening
On-line přístup:	http://www.sciencedirect.com/science/article/pii/S2214426920301142
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