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Chemokine receptor CXCR7 antagonism ameliorates cardiac and renal fibrosis induced by mineralocorticoid excess

Abstract Cardiorenal fibrosis is a common feature of chronic cardiovascular disease and recent data suggests that cytokines and chemokines may also drive fibrosis. Here we tested the hypothesis that CXCR7, a highly conserved chemokine receptor, contributes to cardiac and renal fibrosis. We generated...

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Principais autores: Bing H. Wang, Remy Robert, Francine Z. Marques, Niwanthi Rajapakse, Helen Kiriazis, Charles R. Mackay, David M. Kaye
Format: Artigo
Sprog:Inglês
Udgivet: Nature Portfolio 2024-11-01
Serier:Scientific Reports
Fag:
Fibrosis
Mineralocorticoid excess
Chemokine receptors
CXCR7 antagonist
Online adgang:https://doi.org/10.1038/s41598-024-75789-0
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