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Warburg effect enhanced by AKR1B10 promotes acquired resistance to pemetrexed in lung cancer-derived brain metastasis

Abstract Background Resistance to pemetrexed (PEM), a rare chemotherapeutic agent that can efficiently cross the blood-brain barrier, limits the therapeutic efficacy for patients with lung cancer brain metastasis (BM). Aldo-keto reductase family 1 B10 (AKR1B10) was recently found to be elevated in l...

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Gespeichert in:
Hauptverfasser: Wenzhe Duan, Wenwen Liu, Shengkai Xia, Yang Zhou, Mengyi Tang, Mingxin Xu, Manqing Lin, Xinyu Li, Qi Wang
Format: Artigo
Sprache:Inglês
Veröffentlicht: BMC 2023-08-01
Schriftenreihe:Journal of Translational Medicine
Schlagworte:
Lung cancer
Brain metastasis
Chemotherapeutic resistance
Pemetrexed
AKR1B10
Warburg metabolism
Online-Zugang:https://doi.org/10.1186/s12967-023-04403-0
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