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ELFN1-AS1 promotes GDF15-mediated immune escape of colorectal cancer from NK cells by facilitating GCN5 and SND1 association

Abstract The ability of colorectal cancer (CRC) cells to escape from natural killer (NK) cell immune surveillance leads to anti-tumor treatment failure. The long non-coding RNA (lncRNA) ELFN1-AS1 is aberrantly expressed in multiple tumors suggesting a role as an oncogene in cancer development. Howev...

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Principais autores: Bin Han, Jinsong He, Qing Chen, Min Yuan, Xi Zeng, Yuanting Li, Yan Zeng, Meibo He, Qilin Zhou, Dan Feng, Daiyuan Ma
Format: Artigo
Sprog:Inglês
Udgivet: Springer 2023-05-01
Serier:Discover Oncology
Fag:
Nature killer cell
ELFN1-AS1
GDF15
SND1
Colorectal cancer
GCN5
Online adgang:https://doi.org/10.1007/s12672-023-00675-6
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