Integration of signaling pathway and bromodomain and extra-terminal domain inhibition for the treatment of mutant Kirsten rat sarcoma viral oncogene homolog cancer

Mutant Kirsten rat sarcoma viral oncogene homolog (KRAS) is now a drugable oncogenic driver and the KRAS G12C variant responds clinically to sotorasib and adagrasib that covalently block the cysteine of the active center and inhibit downstream signaling and proliferation. Unfortunately, progression-...

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Detaylı Bibliyografya

Asıl Yazarlar:	Gerhard Hamilton, Sandra Stickler, Barbara Rath
Materyal Türü:	Artigo
Dil:	Inglês
Baskı/Yayın Bilgisi:	Open Exploration Publishing Inc. 2023-10-01
Seri Bilgileri:	Exploration of Targeted Anti-tumor Therapy
Konular:	non-small cell lung cancer kirsten rat sarcoma viral oncogene homolog son of sevenless 1 bromodomain and extra-terminal inhibitors proteolysis-targeting chimeras
Online Erişim:	https://www.explorationpub.com/Journals/etat/Article/1002178
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