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Spatial distribution of tumor-infiltrating T cells indicated immune response status under chemoradiotherapy plus PD-1 blockade in esophageal cancer

BackgroundThe spatial distribution of tumor-infiltrating T cells and its dynamics during chemoradiotherapy combined with PD-1 blockade is little known in esophageal squamous cell carcinoma (ESCC).MethodsWe applied the multiplex immunofluorescence method to identify T cells (CD4+, CD8+ T cells, and t...

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Principais autores: Cihui Yan, Hui Huang, Zhunhao Zheng, Xiaoxue Ma, Gang Zhao, Tian Zhang, Xi Chen, Fuliang Cao, Hui Wei, Jie Dong, Peng Tang, Hongjing Jiang, Meng Wang, Ping Wang, Qingsong Pang, Wencheng Zhang
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2023-05-01
Serier:Frontiers in Immunology
Fag:
esophageal squamous cell carcinoma
spatial analysis
immunotherapy
chemoradiotherapy
PD-1
tumor-infiltrating T cell
Online adgang:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1138054/full
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