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P300/CBP‐associated factor (PCAF)‐mediated acetylation of Fascin at lysine 471 inhibits its actin‐bundling activity and tumor metastasis in esophageal cancer

Abstract Background Fascin is crucial for cancer cell filopodium formation and tumor metastasis, and is functionally regulated by post‐translational modifications. However, whether and how Fascin is regulated by acetylation remains unclear. This study explored the regulation of Fascin acetylation an...

Ful tanımlama

Kaydedildi:
Asıl Yazarlar: Yin‐Wei Cheng, Fa‐Min Zeng, Da‐Jia Li, Shao‐Hong Wang, Jian‐Zhong He, Zhen‐Chang Guo, Ping‐Juan Nie, Zhi‐Yong Wu, Wen‐Qi Shi, Bing Wen, Xiu‐E Xu, Lian‐Di Liao, Zhi‐Mao Li, Jian‐Yi Wu, Jun Zhan, Hong‐Quan Zhang, Zhi‐Jie Chang, Kai Zhang, Li‐Yan Xu, En‐Min Li
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Wiley 2021-12-01
Seri Bilgileri:Cancer Communications
Konular:
acetylation
actin‐bundling
esophageal cancer
fascin
filopodium formation
P300/CBP‐associated factor (PCAF)
Online Erişim:https://doi.org/10.1002/cac2.12221
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