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Therapeutic Potential of an Azithromycin-Colistin Combination against XDR <i>K. pneumoniae</i> in a 3D Collagen-Based In Vitro Wound Model of a Biofilm Infection

A therapeutic combination of azithromycin (AZM) and colistin methanesulfonate (CMS) was shown to be effective against both non-PDR and PDR <i>Klebsiella pneumoniae</i> biofilms in vitro. These anti-biofilm effects, however, may not correlate with effects observed in standard plate assays, nor will t...

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Main Authors: Olena V. Moshynets, Taras P. Baranovskyi, Olga S. Iungin, Alexey A. Krikunov, Viktoria V. Potochilova, Kateryna L. Rudnieva, Geert Potters, Ianina Pokholenko
Format: Artigo
Language:Inglês
Published: MDPI AG 2023-02-01
Series:Antibiotics
Subjects:
MDR/XDR/PDR Gram-negative infection
<i>Klebsiella pneumonia</i>
biofilms
wound model
colistin methanesulfonate
azithromycin
Online Access:https://www.mdpi.com/2079-6382/12/2/293
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