ACSS2-mediated lysine crotonylation attenuates senescence and enhances the therapeutic efficacy of adipose-derived stem cells in inflammatory bowel disease

Abstract Background Inflammatory bowel disease (IBD) remains a significant clinical challenge with limited curative options. Adipose-derived mesenchymal stem cells (ADSCs) hold therapeutic promise, but their anti-inflammatory efficacy is often compromised by cellular senescence. This study investiga...

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Principais autores:	Ming Yuan, Senmao Li, Shaopeng Chen, Minghui Zhu, Runfeng Yu, Junfeng Huang, Guanzhan Liang, Chi Zhang, Xiaowen He, Ping Lan, Xianrui Wu
格式:	Artigo
語言:	Inglês
出版:	SpringerOpen 2026-03-01
叢編:	Cell Regeneration
主題:	Crotonylation ACSS2 Cellular senescence Adipose-derived stem cells Inflammatory bowel disease
在線閱讀:	https://doi.org/10.1186/s13619-026-00285-x
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