Fluconazole nanoparticles prepared by antisolvent precipitation technique: Physicochemical, in vitro, ex vivo and in vivo ocular evaluation

The goal of this research was to prepare and characterize nanonized particles of the antifungal drug, fluconazole (FLZ) using antisolvent precipitation nanonization technique to improve its ocular permeation. The impact of various concentrations of different stabilizers, namely Pluronic F-127 (PL F...

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Autors principals:	Amal El Sayeh F. Abou El Ela, Mohamed Abbas Ibrahim, Yara Alqahtani, Aliyah Almomen, Fadilah Sfouq Aleanizy
Format:	Artigo
Idioma:	Inglês
Publicat:	Springer 2021-06-01
Col·lecció:	Saudi Pharmaceutical Journal
Matèries:	Nanonization Antisolvent precipitation nanonization Stabilizers Fluconazole Ocular delivery
Accés en línia:	http://www.sciencedirect.com/science/article/pii/S131901642100075X
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