Islet vascularization is regulated by primary endothelial cilia via VEGF-A-dependent signaling

Islet vascularization is essential for intact islet function and glucose homeostasis. We have previously shown that primary cilia directly regulate insulin secretion. However, it remains unclear whether they are also implicated in islet vascularization. At eight weeks, murine Bbs4-/-islets show sign...

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Detalhes bibliográficos

Principais autores:	Yan Xiong, M Julia Scerbo, Anett Seelig, Francesco Volta, Nils O'Brien, Andrea Dicker, Daniela Padula, Heiko Lickert, Jantje Mareike Gerdes, Per-Olof Berggren
Formato:	Artigo
Idioma:	Inglês
Publicado em:	eLife Sciences Publications Ltd 2020-11-01
coleção:	eLife
Assuntos:	primary cilia pancreatic islet islet vascularization VEGF-A insulin
Acesso em linha:	https://elifesciences.org/articles/56914
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