Inhibition of MMPs supports amoeboid angiogenesis hampering VEGF-targeted therapies via MLC and ERK 1/2 signaling

Abstract Background In the past decades studies on anti-tumoral drugs inhibiting matrix metalloproteinase (MMPs) were disappointing. Recently, we demonstrated that mature endothelial cells (ECs) and endothelial colony forming cells (ECFCs) can switch between invasion modes to cope with challenging e...

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Detalles Bibliográficos

Principais autores:	Anastasia Chillà, Cecilia Anceschi, Elena Frediani, Francesca Scavone, Tommaso Del Rosso, Giuseppe Pelagio, Antonio Tufaro, Giuseppe De Palma, Mario Del Rosso, Gabriella Fibbi, Paola Chiarugi, Anna Laurenzana, Francesca Margheri
Formato:	Artigo
Idioma:	Inglês
Publicado:	BMC 2023-02-01
Series:	Journal of Translational Medicine
Assuntos:	Angiogenesis Protease inhibitors Amoeboid migration VEGF Endothelial cells ECFCs
Acceso en liña:	https://doi.org/10.1186/s12967-023-03954-6
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