Ceftriaxone alleviates mitochondrial damage through the inhibition of extrasynaptic NMDA receptor-mediated changes in intracellular calcium levels to improve cognitive deficits in APP/PS1 mice

Abstract Background Mitochondrial dysfunction and dysregulated calcium homeostasis contribute to Alzheimer’s disease (AD) pathogenesis. The extrasynaptic N-methyl-D-aspartic acid (NMDA) receptor (eNMDAR) plays a crucial role in calcium influx and subsequent signaling cascades. In individuals with AD...

Descrizione completa

Dettagli Bibliografici

Autori principali:	Li-Rong Liu, Li Li, Li-Li Lu, Shu-Juan Fan, Li-Zhe Liu, Ruo-Bing He, He Li, Xiao-Hui Xian, Wen-Bin Li
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	BMC 2025-12-01
Serie:	Alzheimer’s Research & Therapy
Soggetti:	Alzheimer’s disease Ceftriaxone Extrasynaptic NMDA receptor Cytoplasmic and mitochondrial calcium levels Mitochondrial damage
Accesso online:	https://doi.org/10.1186/s13195-025-01900-w
Tags:	Aggiungi Tag Nessun Tag, puoi essere il primo ad aggiungerne!!