β-Sitosterol β-d-glucoside (BSSG) triggers intestinal inflammation in zebrafish and mouse models prior to neurodegeneration onset

Abstract Background Glucosylated-sterols can be synthetized endogenously, absorbed through the diet or derive from bacterial infection. Their clinical relevance is currently underestimated, even though their imbalance has been associated with an increased risk of neurodegeneration over the lifespan....

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Autori principali:	Francesca Terrin, Sofia Faggin, Edoardo Bizzotto, Davide Santinello, Silvia Cerantola, Giuseppe Borsato, Fabrizio Fabris, Alessandro Scarso, Rosario Licitra, Graziano Guella, Gabriele Sales, Stefano Cagnin, Laura Treu, Luigi Bubacco, Maria Cecilia Giron, Nicoletta Plotegher, Luisa Dalla Valle
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	BMC 2026-05-01
Serie:	Journal of Biomedical Science
Soggetti:	BSSG Glucosylated sterols Intestinal inflammation Gut microbiota Glucocorticoid receptor Gut–brain axis
Accesso online:	https://doi.org/10.1186/s12929-026-01249-8
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