Shikonin from lithospermum erythrorhizon induces pyroptosis in trophoblast cells by activating the CTSB-NLRP3 inflammasome

Background With the decline of global fertility, drug therapeutic of ectopic pregnancy is of great significance. Lithospermum erythrorhizon is using for embryo killing as herbal medicine. Shikonin is the critical nucleus of Lithospermum erythrorhizon; however, the mechanism is still unclear. The stu...

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Principais autores:	Fuling Zeng, Yuling Lai, Yanxi Huang, Fangfang Zhu, Jie Gao, Zhenyue Chen, Lihua Zeng, Min Feng, Pin Qiu, Shuo Yuan, Gaopi Deng
Formato:	Artigo
Idioma:	Inglês
Publicado:	Taylor & Francis Group 2024-12-01
Series:	Annals of Medicine
Assuntos:	Shikonin network pharmacology cathepsin B NLRP3 inflammasome pyroptosis
Acceso en liña:	https://www.tandfonline.com/doi/10.1080/07853890.2024.2394584
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