Extracellular succinate derived from ectopic milieu drives adhesion and implantation growth of ectopic endometrial stromal cells via the SUCNR1 signal in endometriosis

Abstract Background As a dual-function metabolite, succinate has emerged in cell function and plays a key signaling role in linking mitochondrial function to other cellular functions. Succinate accumulation in the cytoplasm is commonly associated with hypoxia in the microenvironment and immune cell...

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Autori principali:	Qi Tian, Jingyao Ruan, Yuning Wang, Yinping Xiao, Qi Cheng, Yun Chen, Mingqing Li, Kaikai Chang, Xiaofang Yi
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	BMC 2024-01-01
Serie:	Cell Communication and Signaling
Soggetti:	Endometriosis Succinate Peritoneal mesothelial cell Endometrial stromal cells (ESCs) Macrophage SUCNR1
Accesso online:	https://doi.org/10.1186/s12964-023-01415-7
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