CD4+ T Cell Fate Decisions Are Stochastic, Precede Cell Division, Depend on GITR Co-Stimulation, and Are Associated With Uropodium Development

During an immune response, naïve CD4+ T cells proliferate and generate a range of effector, memory, and regulatory T cell subsets, but how these processes are co-ordinated remains unclear. A traditional model suggests that memory cells use mitochondrial respiration and are survivors from a pool of p...

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Autori principali:	Stephen P. Cobbold, Elizabeth Adams, Duncan Howie, Herman Waldmann
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Frontiers Media S.A. 2018-06-01
Serie:	Frontiers in Immunology
Soggetti:	T cell differentiation cell fate asymmetric cell division imaging flow cytometry GITR mTOR signaling
Accesso online:	https://www.frontiersin.org/article/10.3389/fimmu.2018.01381/full
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