M1-BMDMs with Wnt5a deletion attenuate liver fibrosis by suppression of Wnt5a/Frizzled 2 axis in hepatic progenitors

Abstract Background Bone marrow-derived macrophages (BMDMs) regulate hepatic progenitor cells (HPCs) differentiation, potentially via the Wnt signaling pathway. While M1-polarized BMDMs (M1-BMDMs) exert anti-fibrotic effects in the liver, Wnt5a is implicated in fibrosis progression. The specific inf...

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Autors principals:	Fei-fei Xing, Dan-yang Wang, Yan-nan Xu, Xin-rui Zheng, Shi-hao Zhang, Meng-yao Zong, Jun-yi Zhan, De-xin Wang, Wei Liu, Jia-mei Chen, Gao-feng Chen, Ping Liu, Cheng-hai Liu, Yong-ping Mu
Format:	Artigo
Idioma:	Inglês
Publicat:	BMC 2025-08-01
Col·lecció:	Cell & Bioscience
Matèries:	Liver cirrhosis Bone marrow-derived macrophage Wnt5a/Frizzled2 signaling axis Hepatic progenitor cells Ductular reaction
Accés en línia:	https://doi.org/10.1186/s13578-025-01467-x
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