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Low-intensity muscle contraction exercise reduces pain sensitivity by modulating peripheral pathology and spinal sensitization in end-stage knee osteoarthritis rats

IntroductionThis study evaluated the effects of low-intensity muscle contraction exercise on pain sensitivity, peripheral pathology, and central sensitization in the spinal dorsal horn in a rat model of end-stage knee osteoarthritis (OA) induced by monosodium iodoacetate (MIA).MethodsSixty-two male...

Ausführliche Beschreibung

Gespeichert in:
Hauptverfasser: Satoko Motokawa, Junya Sakamoto, Ryo Sasaki, Yuki Nishi, Yuichiro Honda, Ayumi Takahashi, Minoru Okita
Format: Artigo
Sprache:Inglês
Veröffentlicht: Frontiers Media S.A. 2025-09-01
Schriftenreihe:Frontiers in Pain Research
Schlagworte:
osteoarthritis
pain
peripheral pathology
central sensitization
low-intensity muscle contraction exercise
Online-Zugang:https://www.frontiersin.org/articles/10.3389/fpain.2025.1644177/full
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