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Helminth driven gut inflammation and microbial translocation associate with altered vaccine responses in rural Uganda

Abstract Vaccine responses are sometimes impaired in rural, low-income settings. Helminth-associated gut barrier dysfunction and microbial translocation (MT) may be implicated. We used samples from a trial of praziquantel treatment-effects on vaccine responses in Schistosoma mansoni (Sm)-endemic Uga...

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Bibliographic Details
Main Authors: Jacent Nassuuna, Joas Sterk, Bridgious Walusimbi, Agnes Natukunda, Ronald Nkangi, Rebecca Amongin, Ludoviko Zirimenya, Emily L. Webb, Alison M. Elliott, Gyaviira Nkurunungi
Format: Artigo
Language:Inglês
Published: Nature Portfolio 2025-03-01
Series:npj Vaccines
Online Access:https://doi.org/10.1038/s41541-025-01116-x
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