Energy crisis and cartilage collapse: metabolic reprogramming of chondrocytes in osteoarthritis

Osteoarthritis (OA), a degenerative joint disease imposing a significant global disease burden, exhibits pathological mechanisms far more complex than mere “cartilage wear”. Previous research has long centered on mechanical wear of articular cartilage and inflammatory responses. However, recent stud...

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Bibliographic Details

Main Authors:	Fangzheng Yang, Qi Wang, Xuesai Zhu, Yizhi Yao, Tengbo Yu, Xiao Xiao
Format:	Artigo
Language:	Inglês
Published:	Frontiers Media S.A. 2026-07-01
Series:	Frontiers in Immunology
Subjects:	chondrocytes energy metabolism extracellular matrix glycolysis osteoarthritis
Online Access:	https://www.frontiersin.org/articles/10.3389/fimmu.2026.1834080/full
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