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eQTLs identify regulatory networks and drivers of variation in the individual response to sepsis

Summary: Sepsis is a clinical syndrome of life-threatening organ dysfunction caused by a dysregulated response to infection, for which disease heterogeneity is a major obstacle to developing targeted treatments. We have previously identified gene-expression-based patient subgroups (sepsis response s...

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Główni autorzy: Katie L. Burnham, Nikhil Milind, Wanseon Lee, Andrew J. Kwok, Kiki Cano-Gamez, Yuxin Mi, Cyndi G. Geoghegan, Ping Zhang, Stuart McKechnie, Nicole Soranzo, Charles J. Hinds, Julian C. Knight, Emma E. Davenport, Jenni Addison, Helen Galley, Sally Hall, Sian Roughton, Jane Taylor, Heather Tennant, Nigel Webster, Achyut Guleri, Natalia Waddington, Dilshan Arawwawala, John Durcan, Christine Mitchell-Inwang, Alasdair Short, Susan Smolen, Karen Swan, Sarah Williams, Emily Errington, Tony Gordon, Maie Templeton, Marie McCauley, Pyda Venatesh, Geraldine Ward, Simon Baudouin, Sally Grier, Elaine Hall, Charley Higham, Jasmeet Soar, Stephen Brett, David Kitson, Juan Moreno, Laura Mountford, Robert Wilson, Peter Hall, Jackie Hewlett, Roser Faras-Arraya, Christopher Garrard, Paula Hutton, Julian Millo, Penny Parsons, Alex Smiths, Duncan Young, Parizade Raymode, Prem Andreou, Sarah Bowrey, Dawn Hales, Sandra Kazembe, Natalie Rich, Emma Roberts, Jonathan Thompson, Simon Fletcher, Georgina Glister, Melissa Rosbergen, Jeronimo Moreno Cuesta, Julian Bion, Ronald Carrera, Sarah Lees, Joanne Millar, Natalie Mitchell, Annette Nilson, Elsa Jane Perry, Sebastian Ruel, Jude Wilde, Heather Willis, Jane Atkinson, Abby Brown, Nicola Jacques, Atul Kapila, Heather Prowse, Martin Bland, Lynne Bullock, Donna Harrison, Anton Krige, Gary Mills, John Humphreys, Kelsey Armitage, Shond Laha, Jacqueline Baldwin, Angela Walsh, Nicola Doherty, Stephen Drage, Laura Ortiz-Ruiz de Gordoa, Sarah Lowes, Helen Walsh, Verity Calder, Catherine Swan, Heather Payne, David Higgins, Sarah Andrews, Sarah Mappleback, Charles Hinds, D. Watson, Eleanor McLees, Alice Purdy, Martin Stotz, Adaeze Ochelli-Okpue, Stephen Bonner, Iain Whitehead, Keith Hugil, Victoria Goodridge, Louisa Cawthor, Martin Kuper, Sheik Pahary, Geoffrey Bellingan, Richard Marshall, Hugh Montgomery, Jung Hyun Ryu, Georgia Bercades, Susan Boluda, Andrew Bentley, Katie Mccalman, Fiona Jefferies, Alice Allcock, Katie Burnham, Emma Davenport, Cyndi Geoghegan, Julian Knight, Narelle Maugeri, Jayachandran Radhakrishnan
Format: Artigo
Język:Inglês
Wydane: Elsevier 2024-07-01
Seria:Cell Genomics
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Dostęp online:http://www.sciencedirect.com/science/article/pii/S2666979X2400171X
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