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Single-cell analysis indicating CCR8 modulates CD8+ tissue-resident memory T cells to attenuates rejection in transplantation

Abstract Immune rejection poses a major challenge in organ transplantation, with tissue-resident memory T (TRM) cells playing a critical role in graft rejection. This study investigated the impact of CCR8 on TRM cells using single-cell RNA sequencing (scRNA-seq), flow cytometry, and immunohistochemi...

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Principais autores: Xueteng Wang, Xinqiang Li, Hailun Cai, Zhuoyu Jia, Xin Zhou, Ruidong Ding, Meiying Song, Huan Liu, Feng Wang, Bin Wu, Kai Zhao, Shipeng Li, Bei Zhang, Dahong Teng, Jinzhen Cai
פורמט: Artigo
שפה:Inglês
יצא לאור: Nature Portfolio 2025-12-01
סדרה:Scientific Reports
נושאים:
Tissue resident memory T cells
Transplantation
CCR8
Immune rejection
גישה מקוונת:https://doi.org/10.1038/s41598-025-32785-2
תגים: הוספת תג
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