Sedentary behavior in mice induces metabolic inflexibility by suppressing skeletal muscle pyruvate metabolism

Carbohydrates and lipids provide the majority of substrates to fuel mitochondrial oxidative phosphorylation. Metabolic inflexibility, defined as an impaired ability to switch between these fuels, is implicated in a number of metabolic diseases. Here, we explore the mechanism by which physical inacti...

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Detalhes bibliográficos

Principais autores:	Piyarat Siripoksup, Guoshen Cao, Ahmad A. Cluntun, J. Alan Maschek, Quentinn Pearce, Marisa J. Brothwell, Mi-Young Jeong, Hiroaki Eshima, Patrick J. Ferrara, Precious C. Opurum, Ziad S. Mahmassani, Alek D. Peterlin, Shinya Watanabe, Maureen A. Walsh, Eric B. Taylor, James E. Cox, Micah J. Drummond, Jared Rutter, Katsuhiko Funai
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Clinical Investigation 2024-06-01
coleção:	The Journal of Clinical Investigation
Assuntos:	Metabolism
Acesso em linha:	https://doi.org/10.1172/JCI167371
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