Microbial metabolite sodium butyrate enhances the anti-tumor efficacy of 5-fluorouracil against colorectal cancer by modulating PINK1/Parkin signaling and intestinal flora

Abstract Colorectal cancer (CRC) is a prevalent global health issue, with 5-fluorouracil (5-FU) being a commonly used chemotherapeutic agent for its treatment. However, the efficacy of 5-FU is often hindered by drug tolerance. Sodium butyrate (NaB), a derivative of intestinal flora, has demonstrated...

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Hlavní autoři:	Yangbo Li, Pengzhan He, Ying Chen, Jiaming Hu, Beiying Deng, Chuan Liu, Baoping Yu, Weiguo Dong
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Nature Portfolio 2024-06-01
Edice:	Scientific Reports
Témata:	Sodium butyrate Colorectal cancer Apoptosis Reactive oxygen species PINK1/Parkin
On-line přístup:	https://doi.org/10.1038/s41598-024-63993-x
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