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Hypo-glycosylated FSH enhances the ovarian microenvironment for follicular development compared to fully glycosylated FSH

Abstract Differential N-glycosylations of follicle-stimulating hormone (FSH) influence follicular development dynamics, significantly affecting assisted reproductive technology outcomes. However, the ovarian microenvironment induced by different FSH glycoforms remains incompletely understood. In thi...

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Principais autores: Jiabin Tang, Zihui Wu, Miaoyu Liu, Linghua Xu, Jiarui Cheng, Chuanlong Wang, Xuedan Zhu, Xinrui Zhou, Liguo Yang, John S. Davis, Guohua Hua
Format: Artigo
Sprog:Inglês
Udgivet: BMC 2025-12-01
Serier:Cell Communication and Signaling
Fag:
FSH
Different glycoforms
Granulosa cells
Theca cells
Oocytes
Cell-cell communication
Online adgang:https://doi.org/10.1186/s12964-025-02576-3
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