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Integrative epigenomic and high-throughput functional enhancer profiling reveals determinants of enhancer heterogeneity in gastric cancer

Abstract Background Enhancers are distal cis-regulatory elements required for cell-specific gene expression and cell fate determination. In cancer, enhancer variation has been proposed as a major cause of inter-patient heterogeneity—however, most predicted enhancer regions remain to be functionally...

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Principais autores: Taotao Sheng, Shamaine Wei Ting Ho, Wen Fong Ooi, Chang Xu, Manjie Xing, Nisha Padmanabhan, Kie Kyon Huang, Lijia Ma, Mohana Ray, Yu Amanda Guo, Ngak Leng Sim, Chukwuemeka George Anene-Nzelu, Mei Mei Chang, Milad Razavi-Mohseni, Michael A. Beer, Roger Sik Yin Foo, Raghav Sundar, Yiong Huak Chan, Angie Lay Keng Tan, Xuewen Ong, Anders Jacobsen Skanderup, Kevin P. White, Sudhakar Jha, Patrick Tan
Format: Artigo
Sprog:Inglês
Udgivet: BMC 2021-10-01
Serier:Genome Medicine
Fag:
Enhancer landscape
Gastric cancer
CapSTARR-seq
Enhancer-promoter interactions
Enhancer heterogeneity
Online adgang:https://doi.org/10.1186/s13073-021-00970-3
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