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Low prevalence of archived integrase strand transfer inhibitors resistance associated mutations in Botswana before the roll out of dolutegravir based first line antiretroviral therapy

BackgroundWe evaluated the prevalence of archived proviral drug resistance mutations (DRMs) associated with resistance to integrase strand transfer inhibitors (INSTIs) shortly before Botswana transitioned in 2016 to using dolutegravir (DTG)-based antiretroviral treatment in first-line regimens.Metho...

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Hoofdauteurs: Dorcas Maruapula, Doreen Ditshwanelo, Marea N. Pema, Ontlametse T. Bareng, Wonderful T. Choga, Natasha O. Moraka, Patrick T. Mokgethi, Kaelo K. Seatla, Catherine K. Koofhethile, Boitumelo J. Zuze, Tendani Gaolathe, Molly Pretorius-Holme, Kebaneilwe Lebani, Joseph Makhema, Vlad Novitsky, Roger Shapiro, Shahin Lockman, Sikhulile Moyo, Simani Gaseitsiwe
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Frontiers Media S.A. 2024-10-01
Reeks:Frontiers in Microbiology
Onderwerpen:
Botswana
HIV
integrase strand transfer inhibitor
HIV drug resistance mutations
antiretroviral therapy
Online toegang:https://www.frontiersin.org/articles/10.3389/fmicb.2024.1482348/full
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