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Impact of L-arginine and L-citrulline supplementation on macrophage responses to Mycobacterium tuberculosis

L-arginine (ARG) availability is a critical determinant of macrophage antimicrobial capacity, as it fuels nitric oxide production and other immune effector pathways essential for restricting Mycobacterium tuberculosis (Mtb), the causative agent of tuberculosis (TB). L-citrulline (CIT), a precursor i...

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Principais autores: Gunapati Bhargavi, Sathyavageeswaran Shreeram, Guenolee Prioult, Ranjeet Kumar, Selvakumar Subbian
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2026-05-01
Serier:Frontiers in Immunology
Fag:
amino acids
antibiotics
antimicrobial response
gene expression
host directed therapy
infection
Online adgang:https://www.frontiersin.org/articles/10.3389/fimmu.2026.1810985/full
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