Mycobacterium tuberculosis Latent Antigen Rv2029c from the Multistage DNA Vaccine A39 Drives TH1 Responses via TLR-mediated Macrophage Activation

Targeting of Mycobacterium tuberculosis (MTB) latent antigens comprises a crucial strategy for the development of alternative tuberculosis (TB) vaccine(s) that protects against TB reactivation. Here, we generated a multistage DNA vaccine, A39, containing the early antigens Ag85A and Rv3425 as well a...

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Principais autores:	Haibo Su, Shengling Zhu, Lin Zhu, Cong Kong, Qi Huang, Zhi Zhang, Honghai Wang, Ying Xu
Format:	Artigo
Jezik:	Inglês
Izdano:	Frontiers Media S.A. 2017-11-01
Serija:	Frontiers in Microbiology
Teme:	latent antigens Mycobacterium tuberculosis macrophages tuberculosis TB vaccine
Online dostop:	http://journal.frontiersin.org/article/10.3389/fmicb.2017.02266/full
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