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The Mycobacterium ulcerans toxin mycolactone causes destructive Sec61-dependent loss of the endothelial glycocalyx and vessel basement membrane to drive skin necrosis

The drivers of tissue necrosis in Mycobacterium ulcerans infection (Buruli ulcer disease) have historically been ascribed solely to the directly cytotoxic action of the diffusible exotoxin, mycolactone. However, its role in the clinically evident vascular component of disease aetiology remains poorl...

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Principais autores: Louise Tzung-Harn Hsieh, Belinda S Hall, Jane Newcombe, Tom A Mendum, Sonia Santana Varela, Yagnesh Umrania, Michael J Deery, Wei Q Shi, Josué Diaz-Delgado, Francisco J Salguero, Rachel E Simmonds
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications Ltd 2025-02-01
coleção:eLife
Assuntos:
mycobacterium ulcerans
mycolactone
Sec61
endothelium
basement membrane
microvasculature
Acesso em linha:https://elifesciences.org/articles/86931
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