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Tetraarsenic tetrasulfide triggers ROS-induced apoptosis and ferroptosis in B-cell acute lymphoblastic leukaemia by targeting HK2

Purpose: Acute lymphoblastic leukemia (ALL) is the most common type of cancer diagnosed in children. Despite cure rates of higher than 85 %, refractory or relapsed ALL still exhibits a bleak prognosis indicative of the dearth of treatment modalities specific for relapsed or refractory ALL. Prior res...

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Principais autores: Wenke Bai, Diandian Liu, Qianyi Cheng, Xingge Yang, Liwen Zhu, Lijun Qin, Jianpei Fang
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2024-02-01
Serier:Translational Oncology
Fag:
Tetraarsenic tetrasulfide
ROS
B-ALL
Hexokinases2
Ferroptosis
Online adgang:http://www.sciencedirect.com/science/article/pii/S193652332300236X
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