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Proteomic profiling of human plasma and intervertebral disc tissue reveals matrisomal, but not plasma, biomarkers of disc degeneration

Abstract Background Intervertebral disc (IVD) degeneration is a common cause of low back pain, and the most symptomatic patients with neural compression need surgical intervention to relieve symptoms. Current techniques used to diagnose IVD degeneration, such as magnetic resonance imaging (MRI), do...

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Principais autores: Christabel Thembela Dube, Hamish T. J. Gilbert, Niamh Rabbitte, Pauline Baird, Sonal Patel, Jeremy A. Herrera, Ivona Baricevic-Jones, Richard D. Unwin, Danny Chan, Kanna Gnanalingham, Judith A. Hoyland, Stephen M. Richardson
Format: Artigo
Sprog:Inglês
Udgivet: BMC 2025-02-01
Serier:Arthritis Research & Therapy
Fag:
Intervertebral disc
Degeneration
Histological grading
Extracellular matrix
Proteomics
Biomarkers
Online adgang:https://doi.org/10.1186/s13075-025-03489-9
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